Furthermore, in HeFH patients and non familial hypercholesterolemia patients with refractory hypercholesterolemia, repeated dosing with ARO-ANG3 significantly reduced mean ANGPTL3 levels between 62 and 92%, LDL-C between 23 and 37%, and triglycerides between 25 and 43% [34]. The gene discussed is ANGPTL3; the disease is familial hypercholesterolemia.