A subset of at least 7 Rabs are physiological substrates of LRRK2 (Steger et al, 2016, 2017) a Ser/Thr kinase that is associated with inherited and sporadic forms of Parkinson’s disease (PD) (Alessi & Sammler, 2018; Di Maio et al, 2018). The gene discussed is LRRK2; the disease is Parkinson disease.