KLK3 and neoplasm: Several authors investigated whether such events could be predicted, finding that prostate-specific antigen (PSA), PSA density (PSAD), percentage of biopsy positive cores (BPC) and tumor grade classification according to the International Society of Urologic Pathology (ISUP) are predictors of unfavorable disease (UD), which includes tumor upgrading and/or upstaging as well as high tumor load, at surgical pathology [2, 4, 5].