So far, as BPCD increased, ETD and ET levels increased accordingly (Fig. 4); however, patients with higher tumor load densities (BPCD > 1.0%/mL) had significantly lower mean levels of ET (Fig. 5, Table 3); furthermore, as BPCD increased, PSAD and PSA levels increased accordingly, however, larger tumor loads associated with lower PSA levels (Supplementary Fig. 1). This evidence concerns the gene KLK3 and neoplasm.