These vital hub genes that may be most closely associated with DM included C-X-C motif chemokine ligand 10 (CXCL10), DExD/H-box helicase 58 (DDX58), interferon-stimulating gene 15 (ISG15), major histocompatibility complex, class I, A (HLA-A), interferon induced protein with tetratricopeptide repeats 3 (IFIT3), signal transducer and activator of transcription 1 (STAT1), 2′-5′-oligoadenylate synthetase 1 (OAS1), interferon alpha inducible protein 6 (IFI6), tripartite motif containing 25 (TRIM25), and guanylate-binding protein 1 (GBP1). Here, ISG15 is linked to dermatomyositis.