The shared targets of Resveratrol and SARS-CoV-2 DEGs may represent the potential therapeutic targets of Resveratrol on COVID-19, which include MMP13, PRKCB, PLAT, KCNH2, ICAM1, PDGFRB, TNF, ITGB3, CSF1R, BCL2A1, and MMP9. This evidence concerns the gene PRKCB and COVID-19.