Recently, a multicenter retrospective European study reported a similar frequency of normal transaminase levels after six months of therapy in adult AIH patients treated with high (≥0.5 mg/kg/day) or low (<0.5 mg/kg/day) predniso(lo)ne doses; however, patients in the high dose group had higher median ALT and bilirubin levels, suggesting that the initial dose should be adapted to disease severity [172]. This evidence concerns the gene GPT and autoimmune hepatitis.