CYP2D6 and autoimmune hepatitis: Another AIH-2 model uses repeated immunizations of C57BL/6 female mice with a plasmid encoding the antigenic region of human CYP2D6 and FTCD, together with the murine end terminal region of cytotoxic T lymphocyte antigen 4 (CTLA-4) as well as IL-12 to achieve tolerance breackdown [124].