Since the GRs are pleiotropically expressed, steroids have systemic side effects of various severity, including weight gain and Cushingoid aspect, insomnia, osteopenia/osteoporosis, hyperglycemia, and, less commonly, brittle diabetes, hypertension, psychosis, cataract and glaucoma, increased risk of infections, hypertrichosis and acne. This evidence concerns the gene BCL2A1 and hypertensive disorder.