Moreover, effector CD4 T cells in AIH are less susceptible to Treg restraints, this defect being due to reduced expression of the receptor molecule Tim-3 (inhibitory receptor T-cell-immunoglobulin-and-mucindomain-containing-molecule-3), which through the binding of galectin-9 expressed by Tregs, induces effector cell death [89]. The gene discussed is CD4; the disease is autoimmune hepatitis.