The genetic susceptibility to AIH is well demonstrated by an HLA-DR3 transgenic mouse on the non-obese diabetic background, which, upon immunization with a DNA plasmid coding human CYP2D6/FTCD fusion protein, develops ANA, anti-LKM1, anti-LC1, chronic immune cell infiltration of the liver parenchyma and fibrosis [98]. This evidence concerns the gene CYP2D6 and autoimmune hepatitis.