Examples of such master regulators are FOXO3, which controls mechanisms linked to MPN, RA, hypercholesterolemia, and hypertriglyceridemia, and PRKCG that controls canonical pathways related to regulation of blood pressure, platelet count, and function and linked to RA (Table 1 and Supplementary Data 19). The gene discussed is FOXO3; the disease is Hypercholesterolemia.