Upon viral infection, endogenous small non-coding RNAs, microRNAs (miRNAs), can also trigger antiviral RNAi12: miRNAs loaded on AGO recognise target transcripts primarily by base-pairing with the seed region (positions 2–8) and suppress hundreds of target transcripts by reducing mRNA stability and/or translation13. The gene discussed is FBXW7; the disease is viral infectious disease.