Among them, 27/RdRP was functionally validated to target the nsp12 region of SARS-CoV-2, confirmed for its transcriptome-wide activity, similar to antifibrotic miR-27a, and experimentally proven to suppress TGF-β-induced lung fibrosis and a collagen-producing gene, COL1A1, in human lung cells. This evidence concerns the gene COL1A1 and pulmonary fibrosis.