TLR7 and systemic lupus erythematosus: Also, the correlation of CNVs in IL12B3, TBX213, and TLR74 with human SLE susceptibility has been reported, and the CNs over 2 were 11.3% for IL12B, 8.5% for TBX21, and 21.6% for TLR7 in SLE patients in the previous reports26,27.