TLR7 and systemic lupus erythematosus: When the CNs between the controls and SLE patients were compared by Wilcoxon rank-sum tests, most genes were significant (TNFAIP3, P < 0.0001; IL12B, P < 0.0001; TBX21, P = 0.0043; and TLR7, P < 0.0001 for both male and female), except for TNIP1 (P = 0.7034).