In the noncancerous region of follicular carcinoma in 4W rats, autophagy regulatory genes including Cdkn2a, Ctss, Cxcr4, Tgfb1, Tnf, and Tp53 were upregulated, whereas Eif2ak3, Mapt, and Pim2, were downregulated. The gene discussed is CDKN2A; the disease is thyroid gland follicular carcinoma.