Conversely, immunofluorescence analysis at 18 months post-irradiation revealed the expression of puncta LC3 and p62 proteins in irradiated medullary carcinoma in 7M rats, but their expression was decreased in the cancerous and noncancerous regions of radiation-induced follicular carcinoma in 4W rats. The gene discussed is SQSTM1; the disease is thyroid gland follicular carcinoma.