These signalling pathways lead to genomic (transcriptional) responses, e.g. MTF-1 regulates target genes with the MRE region (transcription factors, developmental and cell cycle regulating genes)53,56,57, or by chromatin modification with ZnF (C2H2-type Zinc finger proteins—transcription factors acting as tumour suppressors as well as oncogenes)58–60, or by regulating tumour cell migration and invasion60. The gene discussed is MTF1; the disease is neoplasm.