In univariate analysis, CALR-High (vs. Low) (HR = 1.416, 95% CI = 1.069–1.875, p = 0.015), HSPA5-High (vs. Low) (HR = 1.362, 95% CI = 1.029–1.804, p = 0.031), TRIB3-High (vs Low) (HR = 1.361, 95% CI = 1.028–1.803, p = 0.031), age (HR = 1.016, 95% CI = 1.003–1.029, p = 0.015), sex (HR = 0.721, 95% CI = 0.535–0.973, p = 0.032), M stage (HR = 4.748, 95% CI = 1.749–12.889, p = 0.002), and N stage (HR = 1.078, 95% CI = 1.002–1.160, p = 0.045) were significantly correlated with the prognosis of TCGA-HNSCC patients (Table 3). Here, HSPA5 is linked to head and neck squamous cell carcinoma.