ESR1 and epilepsy: Regarding drug targets (Table S8), those involved in transcription (topoisomerase), neurotransmission (GABA receptor, norepinephrine reuptake, acetylcholine receptor, dopamine receptor, and monoamine oxidase), ion balance (L-type calcium channel and sodium channel), hormonal balance (estrogen receptor), and signal transduction (mTOR, TP53, and NFkB pathway) were common to epilepsy-inducing and antiepileptic drugs, suggesting that these targets serve as major nodes regulating TLE.