One patient (NCMR035) had a hypermutated tumour (167 somatic mutations from WES) (Supplementary File 1_Fig. 6), accompanied by a frame-shift deletion in MSH6 (p.Phe1104LeufsX11) and a frame-shift insertion in PALB2 (p.Met1049AspfsX4). The gene discussed is PALB2; the disease is neoplasm.