Beneficial effects of Vismodegib on tumour-stromal interactions have previously been shown27, and a role for Hedgehog pathways in mesothelial-matrix interactions (as opposed to simple driving of cell division) is further suggested by our findings of the upregulation of PTCH2, GJB2, NHS and HOXA7 in SUFU deleted tumours (Table 1). This evidence concerns the gene GJB2 and neoplasm.