MAPT and Alzheimer disease: When we performed weighted gene co-expression network analysis (WGCNA)29 on our NPH data, we identified in total 58 gene co-expression modules, only 3 of which are significantly correlated with either β-amyloid or tau burden (saddlebrown, orange, and darkgrey modules—Fig. 3; see Supplementary Data 2 for full results of WGCNA analysis), consistent with analysis at the single-gene level that a restricted set of genes correlate with AD pathologic traits in this cohort.