To further confirm the relevance of the detected genes for tumor maintenance of DUX4-rearranged samples we tested the role of one gene that was downregulated upon DUX4 silencing in PDX ALL-811 and in NALM-6 cells (Fig. 3g), the DNA-damage-inducible transcript 4-like (DDIT4L; also known as Redd2 or Rtp801L), which has been shown to regulate mTOR signaling and autophagy in mammalian cells. This evidence concerns the gene MTOR and acute lymphoblastic leukemia.