We defined three spatial immunophenotypes: excluded (26%; predominant location of CD8+ T cells at tumor border, not center); ignored (28%; negligible presence of CD8+ T cells neither at border nor center) and inflamed (46%; CD8+ T cells evenly distributed across border and center) (see M&M section for detailed criteria of spatial phenotypes) (Fig. 1a, Supplementary Fig. 2a). The gene discussed is CD8A; the disease is neoplasm.