Although further analyses are required to determine the underlying mechanism for TGFβ/SMAD3 signaling-induced apoptosis in NSCLC, our results established an interplay between USP7 and TGFβ/SMAD3 signaling in regulating cancer cell progression in p53-null NSCLC cells. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.