CASP1 and neoplasm: Last, to understand how inflammasome activation precisely controls anti-tumor immune response in tumor-bearing Havcr2cko mice, the Kuchroo team has utilized three different approaches: (1) caspase-1 inhibition, (2) MCC950 treatment to destroy ASC complex, and (3) blockage of IL-1β/IL-18 axis with the antibodies which was the most vigorous way to lower the tumor temperature.