CD4 and neoplasm: Interestingly, Dixon et al. recently showed that TIM3 hampers anti-tumor immunity of DCs via altering inflammasome and oxidative stress regulation.1 Generation of conditional knock-out mice targeting TIM3 in T cells showed that TIM3 influenced tumor growth of immunogenic MC38 colon carcinoma cells (MC38-OVAdim) only in modest levels with the involvement of both CD4+ and CD8+ T cell subtypes.