GNLY and infection: Based on the distinct expression of granzymes in different groups, we assume that: immune system eliminates infected cells and viruses via a cytotoxic mediator network and is a manifold system; the cytotoxic function is enlarged with pro-apoptotic factors such as GZMB and GNLY over time; in late-stage afterward viral clearance, immune system maintains pro-apoptotic features, which could efficiently avoid repeat infection in the short term.