CD274 and non-small cell lung carcinoma: In a meta-analysis including 20 clinical trials and 2,027 NSCLC patients, the combination of anti-PD1/PD-L1 inhibitors with radiotherapy was associated with significantly improved objective response rate (odds ratio [OR] 2.76, 95% CI 1.06–7.19, p = 0.038) and OS (2-year survival HR 1.77, 95% CI 1.35–2.33, p = 0.000) [85].