Since the first approval for the treatment of hairy cell leukemia [147], IFN-α has also been approved for the treatment of melanoma, follicular non-Hodgkin’s lymphoma, AIDS-related Kaposi’s sarcoma and renal cell carcinoma, while IL-2 was approved for the treatment of renal cell carcinoma and melanoma[148]. Here, IFNA1 is linked to hereditary clear cell renal cell carcinoma.