MM often accompanies by an increase in Cao2+, which leads to changes of CaSR expression in hematopoietic precursor cells, and ultimately red blood cell precursors, megakaryocytes (the precursors of blood platelets), monocytes, and macrophages, all of which express higher levels of the CaSR than white blood cells precursors [81]. Here, CASR is linked to Miyoshi myopathy.