ORAI1 and Miyoshi myopathy: In addition, vitro and vivo experiments show that TRPM7, Orai1 and Stim1 (Orai1 and Stim1 will be described in detail in SOCE) mediated Ca2+ influx regulate MM cell motility and dissemination by orchestrating O-GlcNAylation homeostasis that targets integrin α4 and integrin β7 [68].