In studies, the bone density and bone strength of the lower limbs were significantly reduced in type 2 diabetes mellitus (T2DM) mice, serum osteocalcin levels were significantly reduced, and serum tartrate-resistant acid phosphatase-5p (TRAP) levels were significantly increased, indicating that bone brittleness in T2DM mice was due to increased bone absorption and decreased bone formation [15, 64]. Here, ACP5 is linked to diabetes mellitus.