Finally, there was no difference between time of intervention for hyperglycemia (12.3 ± 1.6 vs. 12.6 ± 3.1 weeks, P = 0.628), glycemic control (FBG 4.39 ± 0.23 vs. 4.66 ± 0.33 mmol/L, P = 0.912; 1 h BG 7.14 ± 1.23 vs. 7.61 ± 1.09 mmol/L, P = 0.175; 2 h BG 6.98 ± 1.31 vs. 6.79 ± 1.22 mmol/L, P = 0.614 and HbA1c 5.2 ± 0.6 vs. 5.4 ± 0.4 %, P = 0.566 at delivery), delivery mode, preterm, newborn weight, or incidence of macrosomia between women with insulin and without (Table 1). This evidence concerns the gene INS and Large for gestational age.