The results showed that NT–proBNP (P < 0.001), age (P < 0.001), creatinine (P < 0.001), cTnT (P = 0.001), blood glucose (P = 0.001), diabetes history (P = 0.010), CKD history (P = 0.023) and STEMI (P = 0.039) were all positively associated with MACE. This evidence concerns the gene NPPB and chronic kidney disease.