Moreover, antidepressant use has been associated with a reduced risk of intubation or death in hospitalized patients with COVID-19 because the inhibition of ASM decreases pro-inflammatory mediators such as IL-2, IL-6, IL-7, IL-10, TNF-α, C-reactive protein (CRP), and D-dimer [22,25,26]. This evidence concerns the gene IL2 and COVID-19.