A 1:2 dilution of pooled immune sera from SpyCEP immunisation or combination immunisations resulted in a significant reduction in IL-8 cleavage compared with nonimmune sera (SpyCEP 22% p < 0.0001, ALL 51% p < 0.001 and NoM 25% p < 0.0001), which equated to 78%, 49% and 75% inhibition of cleavage, respectively. This evidence concerns the gene CXCL8 and acute lymphoblastic leukemia.