CD4 and HIV infectious disease: Virus Env mutations on CD4 binding site likely T cell-mediatedGp70 V1V2 antibodies were lower in HVTN 505 [46] than in RV144 [47]. The response to V3 CRF01_AE also inversely correlated with the risk of HIV infection in vaccine recipients with lower levels of Env-specific plasma IgA and neutralizing antibodies