ACHE and dementia: Nevertheless, to increase the efficacy of donepezil, a well-known acetylcholinesterase inhibitor for dementia therapy, it should be used in combination with NMDA receptor antagonists, such as memantine; benzodiazepine receptor partial inverse agonists, such as AC-3933; or a choline-containing phospholipid choline alphoscerate [6,7,8].