GPX4 and spondylometaphyseal dysplasia, Sedaghatian type: GPx4 deficiency in mice is embryonically lethal, and in humans, rare premature-truncation mutations of GPX4 were found to cause Sedaghatian-type spondylometaphyseal dysplasia, an autosomal recessive, neonatal lethal condition that causes developmental defects in cardiac, nervous, and skeletal systems [105].