The strengths of the present study are that, to the best of our knowledge, this is the first to assess the influence of combining CR and RS exercise on inflammatory markers in young adults, and importantly, we found that the CR–RS combined intervention performed the best in reducing body weight, optimizing body composition, and improving CV health including LDL-C, IL-8, SBP, DBP, IL-8, insulin, and HOMA-IR levels in those with overweight or obesity. Here, INS is linked to obesity disorder.