LE dose-dependently reduced the levels of TSLP, TARC, MDC, and RANTES in the serum and gene expression levels of AD-related IL-25, IL-33, TSLP, TARC, MDC, and RANTES, including CCR4, in the dorsal skin of NC/Nga mice (Figure 6E–H and Figure 8). The gene discussed is CCL5; the disease is Alzheimer disease.