Cytokines and chemokines associated with AD, such as IL-4, IL-6, IL-13, IL-17, IL-31, IL-22, IL-33, TSLP, and MCP-1, downregulate the abundance of pro-FLG and as well as that of the skin barrier-related proteins FLG, IVL, and LOR, and the TJ proteins OCC and ZO-1 [4,31,35,47,77,78], resulting in impaired skin barrier function. The gene discussed is IL33; the disease is Alzheimer disease.