SIRT1 and Insulin resistance: Moreover, resistant dextrin from wheat and corn starch could improve lipid and glucose metabolism in insulin resistance mice by increasing Akkermansia and Prevotella abundances, followed by upregulating the insulin receptor substrate 1 (IRS1)-protein kinase B (Akt)-glucose transporter 2 (GLUT2) signaling pathway as well as upregulating the sirtuin 1 (SIRT1)-adenosine monophosphate kinase (AMPK)-peroxisome proliferators activated receptor α (PPARα)-carnitine palmitoyltransferase 1α (CPR1α) signaling pathway [56].