On the other hand, in T2DM patients Medina-vera et al. demonstrated that a functional food intervention consisting of 16.5 g/day of fiber (including dehydrated nopal, chia seeds, soy protein, and inulin) led to a larger percentage change from baseline of HbA1c (−7.20%, p < 0.05) and CRP (−13%, p < 0.01) (p <0.05) than placebo [78]. This evidence concerns the gene CRP and type 2 diabetes mellitus.