TNF and colorectal cancer: The top ten of canonical pathway maps were summarized, including the pathways of apoptosis and survival _TNFR1 signaling, TNF-family pathway, Granzyme B signaling, anti-apoptotic of TNFs/NF-kB/Bcl-2, role of IAP-protein in apoptosis, IGF family signaling in colorectal cancer, cytoskeleton remodeling, immune response_TLR2 and TLR4 signaling.