In fact, the biomechanical properties of the bone are altered both because of an increased production of pro-inflammatory cytokines and by other RA-related factors that contribute to the bone loss: physical disability, inadequate treatment, disease activity, and seropositivity for RF and ACPA, the latter of which displaying especially aberrant osteoclast-activating effects [20,21]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.