Our findings and mechanistic hypothesis based on our metabolomic approach are supported by a recent report from Pino-de-la Fuente et al. Indeed, the authors recorded positive effects of Physalis peruviana in vivo, i.e., insulin resistance and inflammation improvement in the muscles and liver in a mouse model of diet-induced obesity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.