In the present study, we aimed to examine the acute postprandial effect of fructose, reflecting ad libitum consumption of fructose, using pure fructose drink (35 g fructose), European Coca-Cola (17.5 g fructose) and a blueberry drink (18 g fructose), without and with a pizza, on IL-6, IL-18, MCP-1, ICAM-1 and VCAM-1 levels in T2D and HS. This evidence concerns the gene IL18 and type 2 diabetes mellitus.