Gibbs et al. [105] reported that caffeine in high concentrations (5 mM) inhibits the mammalian target of rapamycin (mTOR) in human myeloid leukemia cells, primary human acute myeloid leukemia cells, and primary human basophils, and affects glycolysis and the release of pro-inflammatory cytokines. The gene discussed is MTOR; the disease is acute myeloid leukemia.