Moreover, Huanhuan et al. [144] examined the effect of caffeine in the inhibition of renal cell carcinoma (RCC) and showed that caffeine may target glucose-6-phosphate dehydrogenase (G6PDH), inhibit G6PDH activity, and disrupt redox homeostasis, and through this, may inhibit RCC tumor growth, which is dependent on G6PDH activity. Here, H6PD is linked to renal cell carcinoma.