Several signaling pathways are involved in leiomyoma progression, including the MAPK signaling pathway, the phosphorylation of extracellular signal-regulated kinases (ERK), the phosphoinositide 3-kinase (PI3K)/Akt pathway, and the wingless-type (Wnt)/β-catenin signaling pathway [30]. This evidence concerns the gene AKT1 and leiomyoma.