SOAT1 and rheumatoid arthritis: Like IL-6 signaling, which is integral to the pain mediated by sensory neurons, and interferon (IFN)-γ, which may potentiate neuropathic pain [36,37,38], multiple type I and II cytokines regulated by the JAK/STAT pathway have also been implicated in pain modulation in RA [9,10,39,40].