Outcomes of cardiovascular (CV) interest in the included RCTs involved anthropometric indices (BW, BMI, waist circumference, hips circumference, BF, FFM, VAT, hips-to-waist ratio), indicators of glucose and insulin metabolism (FPG, Ins, HOMA-IR, Matsuda Index, HbA1c), changes in the NAFLD grade, blood pressure (SAP and DAP), FMD, inflammation markers (TNF1, IL-6, CRP, etc.), indirect carotid intima-media thickness via asymmetric dimethylarginine (ADMA) assay, blood lipid concentrations (HDL, LDL, TC, TG, apolipoproteins, etc.)and cytokines levels. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.