Several observations have also suggested that activation of SIRT1/AMPK signaling may offer critical pharmacological benefits in the treatment of dyslipidemia, obesity, and metabolic syndrome [35,36,37,38], and we found that Ac administration highly enhanced the AMPK and SIRT1 expression levels in the eWAT of the HFD-induced obese mouse model (Figure 4C,D). This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.