Increases in circulating insulin and glucose related to insulin resistance are reported to be involved in the stimulation of hepatic de novo lipogenesis, because glucose and insulin activate the carbohydrate response element binding protein (ChREBP) and sterol regulatory element-binding protein 1 (SREBP-1), respectively, which activate genes associated with de novo lipogenesis [6,7]. Here, MLXIPL is linked to Insulin resistance.