Specifically, at the highest doses of BC (1 g/day/OVX rats, 1.5 g/day/ORX rats, and/or 1.5 g/day/OVX rats, 2 g/day/ORX rats) we observed that both cortical and trabecular bones improved in both OVX and ORX rats (as well as the bone formation marker OC). The gene discussed is BGLAP; the disease is breast cancer.