Van Hoffen E. et al. observed that infants at risk for allergy fed with infant hypoallergenic whey formula enriched in scGOS/lcFOS, or in maltodextrin for comparison, had a significant reduction in the Th1 associated IgG subclasses (i.e., IgG1, IgG2 and IgG3 for human) [64]. The gene discussed is IGHG3; the disease is allergic disease.