Hydroxytyrosol induced functional impairment of the hypoxia inducible factor-1alpha (HIF-1α)/microsomal prostaglandin-E synthase-1 (mPGEs-1)/PGE-2/VEGF axis in HT-29 and WiDr human colorectal adenocarcinoma cells [40]. Here, HIF1A is linked to colorectal adenocarcinoma.