Catalpol inhibited EMT progression through downregulation of the rho associated coiled-coil containing protein kinase 1 (ROCK1) and MMP-2 expression in MG63 and U2OS human osteosarcoma cancer cell lines, and significantly reduced tumor growth in a dose-dependent manner in a xenograft model transplanted with MG63 cells [58]. Here, ROCK1 is linked to osteosarcoma.