TP53 and non-small cell lung carcinoma: In addition, aucubin treatment induced the A549 human non-small cell lung cancer (NSCLC) cell line to enter the G0/G1 phase, arresting cell cycle progression and inducing apoptosis through p53 and Fas and Fas ligand (FasL) signaling, thereby suggesting its involvement in the anti-proliferative activity of lung cancer [45].