PTGS2 and skin cancer: In chronic UVB-induced skin cancer tissues, administration of oleuropein not only significantly inhibited the diameter of subcutaneous blood vessels in ultraviolet B (UVB)-irradiated mice, but also lowered the expressions of VEGF, cluster of differentiation 31 (CD31), and cyclooxygenase-2 (COX-2), which play pivotal roles in angiogenesis [77].