In fact, compared with their respective normotensive strains and models, all experimental models of hypertension studied to date, including the spontaneously hypertensive rat (SHR), Dahl salt-sensitive, angiotensin II (Ang II) and deoxycorticosterone acetate (DOCA)-salt, have altered gut microbiota [3,5,6,7]. This evidence concerns the gene AGT and hypertensive disorder.