In a previous preliminary study [44] in patients with HLP the intraindividual comparison of canned mackerel versus encapsulated fish oil adapted to a higher dose of EPA (2.2 g/day) has shown decreases in serum TG, free fatty acids (FFA), LDL cholesterol, apolipoprotein B and blood pressure in both groups of participants. The gene discussed is APOB; the disease is hyperkeratosis lenticularis perstans.