In agreement with histological improvement of steatosis, the induction of Gm16551 reduced the transcript for acetyl-CoA carboxylase 1 (Acaca), the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis [31]. The gene discussed is ACACA; the disease is steatosis.